The paper is devoted to the socio-philosophical analysis of sex and gender with the help of the comparative historical method of genealogy in the unity of biological, social and symbolic dimensions. The origin, relevance and history of “male – female” relationships are analyzed. It reveals the complexity and multy-dimensionality of social reality including history and tradition, mythology and metaphysics. “Male” and “female” are understood as constitutive social ontological sources of the cultural picture of the world.